Modeling stochastic gene expression: Implications for haploinsufficiency
نویسندگان
چکیده
منابع مشابه
Modeling stochastic gene expression: implications for haploinsufficiency.
There is increasing recognition that stochastic processes regulate highly predictable patterns of gene expression in developing organisms, but the implications of stochastic gene expression for understanding haploinsufficiency remain largely unexplored. We have used simulations of stochastic gene expression to illustrate that gene copy number and expression deactivation rates are important vari...
متن کاملModeling stochastic gene expression under repression.
Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin-like stochastic model. The effects of transcriptional fluctuations in protein synthesis are probed by coupling transcription and translation by an amplificative interaction. In the presence of repression a new term contributes to the noise, which depends on the rate of mRNA production. If the swi...
متن کاملModeling stochastic gene expression in growing cells.
Gene expression is an inherently noisy process. Fluctuations arise at many points in the expression of a gene, as all the salient reactions such as transcription, translation, and mRNA degradation are stochastic processes. The fluctuations become important when the cellular copy numbers of the relevant molecules (mRNA or proteins) are low. For regulated genes, a computational complication arise...
متن کاملStochastic Gene Expression: Modeling, Analysis, and Identification∗
Gene networks arise due to the interaction of genes through their protein products. Modeling such networks is key to understanding life at the most basic level. One of the emerging challenges to the analysis of genetic networks is that the cellular environment in which these genetic circuits function is abuzz with noise. The main source of this noise is the randomness that characterizes the mot...
متن کاملan investigation about the appropriate stochastic modeling framework for agricultural insurance pricing
با توجه به اینکه بیمه محصولات کشاورزی در ایران بیشتر جنبه ای حمایتی دارد و خسارات گزارش شده عموما بیش از حق بیمه های دریافت شده است، در این پایان نامه به جهت تعیین قیمت بیمه محصولات کشاورزی (گندم دیم) از فرآیندهای نوفه شلیک به عنوان مدلی مناسب استفاده شده است. بر اساس داده های صندوق بیمه کشاورزی از خسارات اعلام شده در سال زراعی 1388-1389 گندم دیم، در این پایان نامه حق بیمه خالص و ناخالص این محص...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.26.15641